CBD For Depression: What Does The Research Say?

CBD For Depression

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Depression is a mood disorder that causes a feeling of sadness and loss of interest. Also known as Major Depressive Disorder or Clinical Depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical issues. You may experience difficulty doing typical everyday activities, and sometimes you feel as if life isn’t worth living. So using CBD for depression is an option to get overcome it. CBD is a characteristic compound that has acquired popularity in recent years due to its potential health benefits which include treating depression and several health issues.

CBD for depression
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What Is Depression?

According to American Psychiatry Association, Depression (major depressive disorder) is a serious condition that has a negative impact on how you feel, think, and act. It is, thankfully, treatable. Depression causes feelings of sadness and/or a loss of interest in previously enjoyed activities. It can cause a variety of emotional and physical problems, as well as a reduction in your ability to function normally at work and at home. For a depression diagnosis, symptoms must last at least two weeks and represent a change in your previous level of functioning.

The symptoms can be mild to severe and include: 

  • Loss of Interest in Daily Activities
  • Change in Sleep Pattern
  • Weight Loss
  • Loss of Energy
  • Anger or Irritability
  • Impulsive Behavior
  • Unexplained Aches and Pains
  • Issues in Focusing


CBD For Depression
CBD For Depression

The cause of depression is still unknown. Similarly, as with numerous mental disorders, a variety of factors may be involved, such as:

Biological Differences

Brain Chemistry

People with depression seem to have physical changes in their brains. The significance is still uncertain, however, may eventually help pinpoint causes.

Neurotransmitters are naturally occurring brain chemicals that play a  major role in depression. Research demonstrates that changes in the function and effect of these neurotransmitters and the way of their interaction with neurocircuits play a major role in maintaining mood stability and also play a significant role in depression and its treatment.

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Changes in the body’s balance of hormones may be involved in causing or triggering depression. Chemical changes can result in pregnancy and during the weeks or months after delivery (postpartum) and from thyroid issues, menopause, or various different conditions.

Inherited Traits

Depression is more common in people whose close family members likewise have this condition. Scientists are attempting to discover qualities that might be associated with causing depression.

CBD for depression
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Types Of Depressive Disorders

Depression can be categorized into various types. Some of them include:

1. Clinical Depression

Depression can range in severity from mild, transient melancholy to severe, long-term depression. Clinical depression, also known as major depression or major depressive disorder, is a more severe form of depression. It’s not the same as depression brought on by a loss, such as a loved one’s death, or a medical condition, such as thyroid disease. Many doctors utilize the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM-5) symptom criteria for the major depressive disorder to diagnose clinical depression.

Some symptoms include sleep disturbances, feelings of sadness, reduced appetite, trouble concentrating, recurrent thought of death or suicide, tiredness, loss of interest, and so on.

2. Persistent Depressive Disorder

Dysthymia, or persistent depressive disorder, is a type of depression that lasts for a long time. You might lose interest in everyday tasks, feel despondent, be unproductive, have low self-esteem, and have a general sense of inadequacy. These emotions can continue for years, interfering with your relationships, schoolwork, and daily activities. You may find it difficult to be cheery even on joyous occasions if you have a chronic depressive disorder; you may be characterized as having a gloomy demeanor, continually whining, or incapable of having fun. Coping with depression symptoms can be difficult due to the chronic nature of the persistent depressive disorder, but a combination of talk therapy (psychotherapy) and medication can be beneficial in treating this illness.

Symptoms include hopelessness, lack of energy, loss of interest, tiredness, irritability, excessive anger, feelings of guilt, poor appetite, sleep problems, etc.

3. Bipolar Disorder

Bipolar disorder, formerly known as manic depression, is a mental health illness that involves emotional highs (mania or hypomania) and lows (depression) (depression). You may feel gloomy or hopeless when you are depressed, and you may lose interest or pleasure in most activities. You may feel ecstatic, full of energy, or abnormally irritable when your mood switches to mania or hypomania (a milder form of mania). Sleep, energy, activity, judgment, conduct, and the ability to think clearly can all be affected by mood fluctuations. Mood swings can happen once a year or several times a year. While the majority of people will have some emotional symptoms in between bouts, some will not.

Bipolar I Disorder

At least one manic episode has occurred and may be preceded or followed by hypomanic or significant depressive episodes. Mania can sometimes lead to a disconnection from reality (psychosis).

Bipolar II Disorder

You’ve experienced at least one severe depressive episode and at least one hypomanic episode, but no manic episode.

Cyclothymic Syndrome

You’ve experienced at least two years of hypomania symptoms and depressive symptoms (or one year in adolescents and teenagers) (though less severe than major depression).

Other Kinds

Bipolar and associated illnesses, for example, might be caused by particular drugs or alcohol, or by a physical condition such as Cushing’s disease, multiple sclerosis, or stroke.

4. Postpartum Depression

The birth of a child can elicit a range of strong emotions, from joy and excitement to dread and anxiety. However, it can also lead to something unexpected: depression. After childbirth, most new mothers have postpartum “baby blues,” which include mood changes, crying bouts, anxiety, and problems sleeping. The baby blues usually start two to three days after delivery and can linger for up to two weeks. However, some new mothers suffer from postpartum depression, which is a more severe and long-lasting form of depression. After childbirth, an intense mental illness known as postpartum psychosis may occur. Postpartum depression is not a weakness or a character trait. Sometimes it’s just a complication of giving birth.

Also Read: CBD For Brain

How Does CBD Work?

CBD For Depression
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Understanding how CBD affects the brain begins with a primer on the endocannabinoid system (ECS), the body’s largest system that you’ve never heard of. It manages almost every internal function we have, such as pain management, immune responses, mental functioning, etc.

The ECS is like Big Brother, constantly keeping an eye on things so that if something isn’t working properly, it can intervene. Assume your body produces a significant amount of heat following a workout. Endocannabinoids bind to receptors, in this case, alerting the ECS that it’s time to get your body to cool down by sweating.

Also Read: Can Postpartum Depression Treat With CBD?


Tetrahydrocannabinol is one of the most common cannabinoids found in cannabis (THC). It is the compound that makes you feel “high.”

THC, like endocannabinoids, interacts with your ECS by binding to receptors once it enters your body. Its potency stems from its ability to bind to both CB1 and CB2 receptors.

This allows it to have a wide range of effects on your body and mind, some of which are preferable to others. THC, for example, may help with pain relief and appetite stimulation. It can, however, cause paranoia and anxiety in some people.

Experts are currently investigating methods for producing synthetic THC cannabinoids that only interact positively with the ECS. The other major cannabinoid found in cannabis is cannabidiol (CBD). CBD, unlike THC, does not cause a “high” and has few to no negative side effects. CBD’s interaction with the ECS is unknown to experts. They do know, however, that it does not bind to CB1 or CB2 receptors like THC does.

Many people believe it works by preventing endocannabinoid breakdown. As a result, they can have a greater impact on your body. Others believe CBD binds to an as-yet-unknown receptor. While the exact mechanism by which CBD works is still being debated, research suggests that it can help with pain, nausea, and other symptoms associated with a variety of conditions.

Also Read: Can CBD Oil Help With The Symptoms of OCD

CBD For Depression


CBD for depression
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Depression and anxiety disorders are the most prevalent mental health issues that can have long-term consequences for a person’s health, social life, workability, and overall well-being.

A doctor may prescribe prescription medicines to aid in the treatment or management of depression. Many of these medications have unpleasant side effects, such as mood swings, insomnia, and sexual dysfunction.

In preliminary studies, CBD showed promise as a treatment for both depression and anxiety, and has no side effects.

The findings of a 2014 study may help explain why CBD may be useful in treating depressive episodes. They show that CBD appears to have a positive interaction with serotonin receptors in the brain in most studies.

Serotonin influences a variety of bodily functions, including a person’s emotional state and feelings of well-being or happiness. Keeping serotonin levels balanced is frequently a key therapy for people suffering from depression.

CBD And Depression – What The Research Says

Animal studies have yielded some support for the use of CBD to treat depression. According to the authors of the 2014 review, findings from various studies suggest that CBD acts as an antidepressant and antianxiety compound in animal models of depression.

Many studies have shown CBD’s anti-stress and antidepressant activity in animal models, according to the authors of a 2018 review. After short or long-term use, the compound has a clear anti-stress effect. CBD was found to be an antidepressant in some studies.

The researchers also discovered that the compound worked without directly activating the brain’s endocannabinoid receptors, which may indicate that CBD is less likely to become habit-forming or addictive.

CBD has even been studied for its potential to help people with opioid use disorder reduce cravings. According to a 2018 study, CBD shows promise as a quick-acting antidepressant. Most CBD researchers who conduct animal studies call for more direct human research, but their preliminary findings are an important step toward understanding how CBD works in the body.

CBD For Panic And Anxiety


CBD for depression
CBD Isolate


Some human studies suggest that CBD may be beneficial for issues other than depression, such as anxiety or panic disorder.

In 2017, a reliable source investigated the potential benefits of CBD for panic disorder and discovered some promising results.

Panic disorder, according to the authors, affects about 5% of the global population and causes unexpected and recurring panic attacks.

According to one study in the review, a single dose of 300 milligrams (mg) of CBD caused a significant decrease in anxiety levels after a simulated public speaking test in human models. Another study discovered that 600 mg of CBD reduced anxiety measures significantly in people with social anxiety disorder.

Also Read: Can Postpartum Depression Treat With CBD?

Broad-Spectrum vs. Isolate vs. Full-Spectrum


CBD products have high levels of CBD as well as trace amounts of other cannabinoids like CBG, CBN, and CBC. The main difference is that broad-spectrum CBD contains no THC. Many people are aware of THC’s negative effects on the body and wish to avoid it completely. This is where CBD’s broad spectrum of action comes in. Broad-spectrum CBD products, as opposed to CBD isolate, benefit from the Entourage effect (the purest form of CBD). Broad-spectrum CBD products have potent antibiotic, antiseizure, and anti-inflammatory properties, and can aid in the treatment of a variety of conditions associated with these symptoms.


CBD Isolate is a term used to describe hemp-derived products that only contain CBD. These items are ideal for those who want to avoid traces of other cannabinoids like CBG, CBN, or THC. CBD isolate products are extremely popular among those who prefer to consume CBD in its purest form. While the addition of other cannabinoids can increase the effectiveness of CBD, research suggests that CBD isolate may still be beneficial for a number of physical and psychological conditions in the body.


Full-spectrum CBD products contain a high concentration of CBD as well as trace amounts of other cannabinoids like CBG, CBN, and THC. Many studies suggest that when two or more cannabinoids interact, they can increase the effectiveness of each other while also providing their own health benefits. This occurrence is known as the Entourage Effect. Full-spectrum CBD products, according to a 2011 study published in the British Journal of Pharmacology, can help with a variety of conditions such as inflammation, anxiety, fungal infections, chronic pain, seizures, cancer, and so on. According to the study, CBD helps to reduce the negative effects of THC, such as hunger and experiencing psychoactive effects.

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Can I Become Addicted To CBD?


CBD For Depression 
broad Spectrum CBD


Addiction is defined as the continued use of a substance despite the fact that it causes negative problems in a person’s life and makes it difficult to control its use. Pure CBD, unlike the chemical THC found in marijuana, does not produce a “high.” Furthermore, there is no evidence that CBD can cause misuse or dependence, nor that CBD causes public health problems, according to the World Health Organization.

However, while pure CBD is not considered addictive, CBD products may contain THC, which can be addictive. This is due to the fact that these products are sold as supplements and thus are not regulated by the FDA. If you are concerned about CBD’s addictive potential, consult with your healthcare provider to determine whether CBD is right for you.

The Ideal Dosage For CBD

One of the great mysteries is that determining the optimal CBD dose is not an exact science. And doctors agree that there is no one universal CBD dosage because different people (and animals) respond to different CBD dosages.

Experts also agree that CBD works best when taken on a consistent basis—daily, often twice a day—because the effects can take time to build—sometimes months (though, some people report feeling less angsty right away).

And the best way to find out what works for you is to start with a low dose and gradually increase it if necessary (follow the recommended dosage instructions on the bottle and talk to your doctor). It may not take as long for someone suffering from mild symptoms to feel the effects as someone suffering from more severe anxiety or depression. The ultimate goal is to find the lowest effective dose. Work with your doctor and give yourself plenty of time to figure everything out.

Also Read: Should You Take CBD Capsules With Or Without Food

What To Know Before Buying CBD


CBD for depression
CBD Tincture


Because CBD oil does not contain THC, it is legal to purchase and use in the United States. When sold outside of states where medical and recreational marijuana use is legal, the purity of CBD is unregulated. That is why conducting research and asking questions about brands is critical.

It is also critical to inquire about the CBD’s origin and purity. Where did this CBD oil come from? (Ideally, it should be close to home.) Is it normal? What third-party testing is performed to ensure that the CBD is pure, safe, and free of contaminants? Transparency is critical, as it has always been. If a company refuses to share information, be wary. There are a plethora of trustworthy CBD oil retailers eager to educate.

Also Read: Does CBD Show Up On A Urine Test?

Buying CBD For Depression

Cibadol is a great website to buy CBD products from. They source their materials from Colorado farms and have all-natural ingredients for optimal purity and efficacy.

CBD Tinctures

If you are looking to incorporate some wellness into your daily routine, you can try Cibadol’s CBD tinctures, which are made with CO2 extracted full-spectrum hemp oil, and non-GMO sunflower lecithin, and MCT oil to improve absorption and bioavailability and provide a consistent, high-quality CBD experience every time. Place a few drops under your tongue, allow the tincture to penetrate for a few moments, and then swallow.

CBD Pills

CBD pills are ideal for those looking for a quick, easy, and discreet way to medicate. One of the most significant advantages of CBD edibles is their low cost. Simply take these CBD-infused pills whenever you need a pick-me-up. Simply take one, swallow it with a glass of water, and let these potent plant compounds work to balance and protect the body’s vital systems and tissues.

CBD Gummies

CBD Gummies are all the rage in the CBD world. Why? Because they come in a variety of colors, shapes, and CBD concentrations. Gummies are a discreet and easy way to consume CBD, especially for first-time users who want maximum accessibility. You can try Classic Mixed Berries CBD Gummies as well as Citrus Gummies, which contain honey, fruit pectin, dextrose, and tapioca syrup.

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Final Thoughts On CBD For Depression

CBD is becoming a popular treatment for a variety of health issues, including depression. Speak with your healthcare provider if you want to try CBD.

Interesting Reads:

CBD For Brain Fog: How Can CBD Help With Mental Clarity?

CBD For Acne: How To Get Rid of Acne With CBD?

What is CBDA: CBDA vs CBD

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