Full Spectrum CBD & The Entourage Effect

Entourage Effect cbd

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Before we begin with what the CBD entourage effect is, let’s understand the basics of CBD and the kind of effects it has on our body.

Cannabidiol (CBD) is known for its medicinal properties and is an extract of cannabis or hemp plants. It has been proven to be beneficial for anxiety, stress, rashes, and inflammations. Moreover, the products are non-intoxicating and safe to use.

The research on CBD had been extensive and, it is now becoming the medication of the modern era. Over the last few years, it has become easier to get CBD around the world. It comes in various products such as oil, edibles, vapes, capsules, and so on. Get high-quality Full Spectrum CBD Oil from Cibadol.

Researchers have found that CBD has added effectiveness when it is combined with other terpenes and flavonoids like CBG and CBN. This is called the entourage effect. In this article, we will discuss more on the basics of the CBD entourage effect.

What is the Entourage Effect of CBD?

Entourage Effect of CBD
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When multiple compounds from the hemp plant are combined, their medicinal effects may be altered or enhanced. The psychoactive capacities and flavors may also be affected, thus creating distinct products with a variety of characteristics. This is known as CBD entourage effect.
Many researchers who work closely with the hemp plants believe that the entourage effect can significantly increase the medicinal properties of CBD, either by magnifying their own properties or adding up to their list of therapeutic applications. According to users and other people who advocate the use of CBD, the group dynamics of the entourage effect can create emergent properties that may not otherwise be present in THC or CBD.

The therapeutic benefits of the hemp plants arise due to their ability to emulsify with the naturally occurring endocannabinoid system in the brain and throughout the central nervous system. The endocannabinoid system is designed to link with the various cannabinoids produced within the body, but compounds found in the hemp plants can also blend in with them just as efficiently.

The entourage effect is believed to come from combining different cannabinoids or combining cannabinoids with terpenes or flavonoids. Terpenes are organic essential oils with distinct aromas and flavors. The characteristics of individual CBD products are usually determined by the relative concentrations of specific terpenes present in them. As of now, most of the research around the entourage effect is focused on the interactions between THC and CBD, and to be precise, how CBD might affect THC.

Contribution of Chemical Compounds in the Entourage Effect

Entourage Effect cbd
Entourage Effect CBD


Cannabinoids, also known as phytocannabinoids, naturally occur within the hemp plant. The most famous and abundant cannabinoids in cannabis are THC and CBD.
Cannabinoids interact with cannabinoid receptors inside the endocannabinoid system and are eventually responsible for the effects commonly associated with THC and CBD.

These well-known cannabinoids are beneficial in their own ways; however, there are additionally other lesser-known cannabinoids that research has shown to have benefits of their own:

  • Cannabinol (CBN)
  • Cannabigerol (CBG)
  • Cannabichromene (CBC)
  • Tetrahydrocannabivarin (THCV)
  • Cannabidivarin (CBDV)

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They’re an essential part of the entourage effect, contributing their own unique health benefits.
Terpenes exist in every plant. Terpenes are considered the essential oils of a plant. Due to this, each plant has its own unique aroma, and flavor, each plant has its particular fragrance and flavor. In cannabis, they’re produced in the same glands as cannabinoids.

Following are a couple of the most prevalent terpenes found in the hemp plant.


Myrcene is the most abundant terpene in hemp and has an aroma similar to that of cloves. It is known for its calming effects. It’s likewise found in hops, mango, and thyme.


Limonene is the second most basic terpene found in hemp and emits a citrusy fragrance. It is said to help increase well-being, focus, and attention. It is likewise found in citrus fruits, rosemary, mint, and pine.


Pinene has the fragrance of pine and is known to support energy levels and concentration. It can likewise be found in rosemary.


Like terpenes, flavonoids are found in a wide range of plants and are responsible for their color. The ravishing greens of kale, bright hues of blueberries, and deep red color of beets aren’t the only things flavonoids are liable for. They likewise collaborate with different chemicals in the plant during different growth stages.

Research suggests that flavonoids are beneficial for health, as they help support homeostasis, or balanced health, in the body.

Evidence Supporting the Entourage Effect


Ethan Russo, a neurologist who serves as the Director of Research and Development at the International Cannabis and Cannabinoids Institute in Prague states, “The biggest influence on THC is CBD”. It is said that no one else in the industry has gone to greater lengths to prove the existence of the entourage effect than Ethan Russo. This article shows how he has been scouring the scientific literature in search of the footprints of the entourage effect for decades.

To show the evidence of CBD’s impact on THC, Russo puts light on a 2010 clinical trial that involved the pain reliever Sativex. Sativex is prescribed to patients with multiple sclerosis and includes a balanced mixture of THC and CBD. In another controlled study, Sativex was given to individuals suffering from pain associated with cancer. Several participants enrolled in the research and received a preparation of pure THC extract, while others were given a placebo. Sativex proved to offer a significant pain-relieving experience in 40% of the patients who took it. This made Sativex twice as potent as the THC extract. To further make it interesting, this difference was seen even when the THC content in each preparation was quite similar. This means that the CBD content somehow increased the pain-relieving potency of the THC. Additional research indicates that Sativex does not particularly produce the psychoactive side effects that are usually experienced by the people who consume pure THC.

Another study from 2016, compared the experiences of cannabis users who smoked pure THC with the people who smoked cannabis products with the people who smoked pure THC. Researchers say that people who smoked pure THC face memory problems and other cognitive difficulties, while those who smoked THC and CBD combined did not experience any of these issues.

Final Thoughts

We hope this article has helped you understand the entourage effect and the studies going on for the same. As you can see, there’s a lot of anecdotal evidence regarding the entourage effect that motivates researchers to continue their quest for the truth.

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