Cannabidiol (CBD) and Cannabidiolic acid (CBDA) are both well-known and abundant chemical compounds native to cannabis and hemp plants
CBD, the major non-psychoactive cannabinoid in cannabis, has been all around researched for its potential health benefits and is presently thought to be able to treat epilepsy, inflammation, anxiety disorders, and various other common physical and neuropsychiatric conditions. By comparison, CBDA has pulled in substantially less attention from the public, the scientific community, and the media, regardless of being the precursor to CBD formation and promising results in early pre-clinical research.
What is CBDA?
CBDA (Cannabidiolic acid) is one of many compounds produced by cannabis and hemp. It converts to the well-known cannabinoid CBD (cannabidiol) over time and when exposed to heat.
Cannabinoids are cannabis compounds that interact with our bodies to produce medical and recreational effects, from pain and stress relief to euphoria. You’ve probably known about CBD and THC—these are the most well-known cannabinoids, and both initially originate from the precursor cannabinoid known as CBGA (Cannabigerolic acid).
Once CBDA has been formed, it’s then converted into CBD by warm decarboxylation, whereby heat causes the molecule to lose its acidic carboxyl group. This decarboxylation process occurs either instantly, for example, when the cannabis material is lit and smoked or vaporized, or by slow degradation over time if the plant material is left to sit at room temperature.
So, despite being abundant in raw cannabis, clients are not actually much exposed to CBDA, as it gets converted from its “raw” form into CBD by the common consumption methods. For individuals who want to consume CBDA, have to use rare or conventional consumption methods, like CBD topical creams, CBD tinctures, and many more.
Research on CBDA
While most cannabinoids tie straightforwardly with either the CB1 or CB2 receptors, CBDA doesn’t work thusly. All things considered, CBDA cooperates with the endocannabinoid framework by hindering the cyclooxygenase-2 (COX-2) catalyst. COX-2 compounds are associated with inflammation after an injury or infection, so by blocking COX-2 enzymes, CBDA can relieve inflammation and associated pain
CBDA is also thought to be a powerful treatment for nausea and anxiety. A 2013 study from researchers in Guelph, Canada, discovered that CBDA was multiple times more impressive than CBD in binding to a particular serotonin receptor linked to anti-nausea and anti-anxiety effects when administered along with low-doses of the traditional anti-nausea drug for chemotherapy patients. In one rodent study, researchers discovered CBDA affected levels of serotonin, a chemical produced by nerve cells to help in signaling between cells. Serotonin is fundamental to core human functions like motor skills, sleeping, eating, digestion, and emotions.
Similarly that it controls nausea, CBDA may likewise be a powerful anticonvulsive. In fact, researchers have shown that CBDA has 100 times the affinity for the 5-HT receptors compared with CBD; one explanation is that CBDA has more prominent bioavailability, so the body can utilize the compound with less exertion and in less time. This same receptor affinity could also mean that CBDA could maybe effectively fight depression. All things considered, CBDA deals with the 5-HT receptors similarly as a particular serotonin reuptake inhibitor (SSRI) antidepressant medication would
CBDA( Cannabidiolic acid) might be helpful with anxiety, depression, seizures, inflammation, and chronic pain just like CBD but at much smaller doses.